Solidsizer | Canty

It is employed to ensure that excipients (like Microcrystalline Cellulose or Lactose) and active pharmaceutical ingredients (APIs) have consistent particle size and shape distributions before they enter the production line. Advantages Over Traditional Methods

| Problem | Likely Cause | Solution | |---------|--------------|----------| | Blurry images | Flow gap too wide for small particles | Reduce gap to 1.5× largest particle | | Double images (ghosts) | Strobe pulse too long or particle velocity too high | Reduce pulse width (to 50 ns) or lower flow | | No particles visible | Window fouled | Run purge cycle or offline clean | | Counts erratic | Air bubbles in line | Install degasser or increase backpressure | | False high counts | Threshold too low (noise detected) | Increase gray threshold value |

: The integrated CantyVision™ Software measures multiple parameters for every particle, including area, perimeter, and both major and minor axes. canty solidsizer

While used frequently in labs, the technology can be integrated directly into production lines for real-time process monitoring.

To understand the significance of the Canty SolidSizer, one must first recognize the limitations of traditional particle sizing methods. Conventional techniques, such as sieving, laser diffraction, or sedimentation, are inherently offline processes. They require a technician to extract a small sample from a large production batch. This approach presents two critical flaws. First, the sample may not be truly representative of the whole, leading to sampling errors. Second, and perhaps more importantly, there is a significant time lag between sampling and results. By the time a lab report indicates a problem—such as oversized granules or excessive fines—the production line may have already processed tons of out-of-spec material. In high-value industries, this lag translates directly into substantial financial loss and waste. It is employed to ensure that excipients (like

Compared to standard laser diffraction or sieving, the SolidSizer offers several technical benefits:

By providing high-resolution, image-based data, the serves as a critical tool for Quality by Design (QbD) initiatives, helping manufacturers maintain strict control over their particulate processes. principal component analysis of granule size distributions To understand the significance of the Canty SolidSizer,

: Analyzing powder morphology and identifying black speck contaminants or defects.