Aldosterone normally acts on the collecting duct of the kidney to increase sodium reabsorption and potassium secretion via epithelial sodium channels (ENaC) and Na⁺/K⁺-ATPase pumps . With less aldosterone, potassium secretion decreases, leading to potassium retention.
Heparin impairs the production of , a hormone produced by the adrenal cortex (specifically the zona glomerulosa ). Aldosterone is essential for regulating sodium and potassium levels. When its production is blocked, the body loses its primary mechanism for excreting potassium, leading to hyperkalemia. how does heparin cause hyperkalemia
While many people can compensate for the drop in aldosterone, the effect is more pronounced in individuals with pre-existing risk factors. Aldosterone normally acts on the collecting duct of
Here is a breakdown of how this process works: Aldosterone is essential for regulating sodium and potassium
Both unfractionated heparin (UFH) and can induce hyperkalemia, but the risk appears slightly lower with LMWH.
Heparin causes hyperkalemia primarily by , which reduces potassium excretion in the kidneys.