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Anaphylaxis is a systemic allergic reaction that involves multiple organ systems. It is characterized by the rapid release of histamine and other mediators from mast cells, leading to vasodilation, increased permeability, and smooth muscle contraction. According to the World Health Organization (WHO), anaphylaxis affects approximately 1-2% of the general population, with a mortality rate of 0.5-1.5 per 100,000 person-years. syok anafilaksis pdf

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The most common causes of anaphylaxis include:

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