Prison Break Season 3 premiered on September 14, 2007, and concluded on May 12, 2008. The season consists of , which is the standard number of episodes for most television seasons.

The brought Hollywood production to a standstill. Many shows airing at that time had their seasons cut short or placed on indefinite hiatus. Because the writers were on the picket lines, Prison Break was forced to wrap up its Sona storyline earlier than originally planned.

Season 3 originally aired from September 17, 2007, to February 18, 2008.